ZNF280A

Across TCGA patient cohorts, ZNF280A mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF280A-associated genes across cancer lineages are ASNS, C-Raf, and EGFR_pY1068. Each is linked with ZNF280A in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF280A-to-partner and partner-to-ZNF280A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ZNF280A-low versus ZNF280A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF280A→partner) and Y-score (partner→ZNF280A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ASNS →	+0.626	+3.000	.011	.036	2	3
UCEC	C-Raf →	+0.193	+2.000	.001	.030	3	2
UCEC	EGFR_pY1068 →	-0.259	-2.222	.015	.011	3	1
UCEC	eIF4E →	+0.196	+2.335	.028	.018	3	1
UCEC	A-Raf_pS299 →	-0.109	-3.000	.031	.036	3	1
UCEC	FoxM1 →	+0.276	+2.222	.012	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ASNS by ZNF280A expression — SKCM

Explore this box plot interactively →