ZNF280A

Across TCGA cell cohorts, ZNF280A mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF280A-associated genes across cancer lineages are GPR32, ASB15, and NXNL1. Each is linked with ZNF280A in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF280A-to-partner and partner-to-ZNF280A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR32 grouped by ZNF280A-low versus ZNF280A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF280A→partner) and Y-score (partner→ZNF280A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPR32 →	+0.108	+3.999	<.001	.004	3	1
LUNG_NSCLC_LUAD	ASB15 →	+0.021	+5.070	<.001	.001	3	1
LUNG_NSCLC_LUAD	NXNL1 →	+0.032	+4.228	<.001	<.001	3	1
LUNG_NSCLC_LUAD	FOXB2 →	+0.831	+4.266	<.001	.004	3	1
LARGE_INTESTINE	H1-1 →	+0.065	+2.791	<.001	.005	3	1
LARGE_INTESTINE	BRDT →	+0.106	+2.906	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

GPR32 by ZNF280A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →