Across TCGA patient cohorts, ZNF28 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF28-associated genes across cancer lineages are p38-MAPK_pT180_Y182, p62 Lck ligand, and PRDX1. Each is linked with ZNF28 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF28-to-partner and partner-to-ZNF28 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF28→partner) and Y-score (partner→ZNF28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.371	-1.736	.008	.006	3	3
LUSC	p62 Lck ligand →	+1.030	+2.179	<.001	.035	3	3
LUSC	PRDX1 →	+0.301	+2.179	.020	.035	3	3
LUSC	4E-BP1 →	+0.520	+2.821	.004	.035	3	3
UCEC	Shc_pY317 →	-0.113	-2.087	.017	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.613	+1.697	.001	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration

ZNF28 survival (RNA) · tumor vs normal (RNA) · all ZNF28 data types