Across TCGA patient cohorts, ZNF277 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF277-associated genes across cancer lineages are MEK1, 14-3-3_beta, and eIF4E. Each is linked with ZNF277 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF277-to-partner and partner-to-ZNF277 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF277→partner) and Y-score (partner→ZNF277) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.484	+3.247	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.096	-2.074	.012	.005	3	1
UCEC	eIF4E →	+0.165	+2.087	.041	.005	3	1
UCEC	IGFBP2 →	-0.672	-1.678	.006	.023	3	1
UCEC	JNK2 →	+0.222	+2.331	.003	.019	3	1
UCEC	Ku80 →	+0.186	+1.335	.040	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

ZNF277 survival (RNA) · tumor vs normal (RNA) · all ZNF277 data types