ZNF276

Across TCGA patient cohorts, ZNF276 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF276-associated genes across cancer lineages are eIF4E, VEGFR2, and MSH6. Each is linked with ZNF276 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF276-to-partner and partner-to-ZNF276 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZNF276-low versus ZNF276-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF276→partner) and Y-score (partner→ZNF276) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.189	+3.013	.030	.018	3	3
BLCA	VEGFR2 →	+0.483	+3.000	.008	.036	3	2
UCEC	MSH6 →	-0.526	-2.459	<.001	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.761	+3.479	.001	.002	3	2
UCEC	14-3-3_beta →	-0.129	-3.295	.001	.009	3	1
UCEC	eEF2 →	+0.359	+1.874	.014	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eIF4E by ZNF276 expression — UCEC

Explore this box plot interactively →