ZNF276

Across TCGA cell cohorts, ZNF276 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF276-associated genes across cancer lineages are TCP11X2, GABRG1, and DEFA4. Each is linked with ZNF276 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF276-to-partner and partner-to-ZNF276 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCP11X2 grouped by ZNF276-low versus ZNF276-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF276→partner) and Y-score (partner→ZNF276) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TCP11X2 →	+0.123	+5.087	<.001	.004	3	1
LARGE_INTESTINE	GABRG1 →	+0.009	+3.196	.001	.007	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPIFA1 →	+0.129	+3.688	.002	.002	3	1
LARGE_INTESTINE	FAM205A →	+0.020	+3.614	<.001	.006	3	1
LARGE_INTESTINE	WNT8A →	+0.018	+3.632	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

TCP11X2 by ZNF276 expression — URINARY_TRACT

Explore this box plot interactively →