ZNF275

Across TCGA patient cohorts, ZNF275 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF275-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and FASN. Each is linked with ZNF275 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF275-to-partner and partner-to-ZNF275 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZNF275-low versus ZNF275-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF275→partner) and Y-score (partner→ZNF275) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.191	-1.343	.004	.002	3	2
UCEC	A-Raf_pS299 →	-0.091	-1.716	.004	.003	3	2
UCEC	FASN →	+0.241	+1.353	.021	.013	3	2
UCEC	MSH2 →	-0.153	-1.388	.013	.041	3	2
SKCM	p38-MAPK_pT180_Y182 →	-0.414	-3.000	.038	.036	3	2
UCEC	PCNA →	+0.157	+1.222	.006	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

EGFR_pY1068 by ZNF275 expression — UCEC

Explore this box plot interactively →