ZNF274

Across TCGA patient cohorts, ZNF274 protein abundance is significantly associated with the RNA expression of many other genes, with 2,339 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ZNF274-associated genes across cancer lineages are SMCO4, MIR6876, and RPL29P7. Each is linked with ZNF274 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF274-to-partner and partner-to-ZNF274 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZNF274 versus SMCO4 in GBM, with a Pearson correlation of -0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF274→partner) and Y-score (partner→ZNF274) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMCO4 →	-1.024	-0.955	.001	.002	3	2
GBM	MIR6876 →	-2.082	-1.207	<.001	<.001	3	2
BRCA	RPL29P7 →	+0.742	+0.651	.007	<.001	3	2
GBM	TAGLN →	-1.712	-0.958	.004	.005	3	2
GBM	ACTG2 →	-2.277	-1.075	.002	.001	3	2
GBM	LIMS1-AS1 →	-0.899	-1.252	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,339 associations by consensus.

ZNF274 vs SMCO4 — GBM

Explore this scatter interactively →