ZNF274

Across TCGA patient cohorts, ZNF274 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF274-associated genes across cancer lineages are TFRC, TIGAR, and eIF4E. Each is linked with ZNF274 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF274-to-partner and partner-to-ZNF274 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by ZNF274-low versus ZNF274-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF274→partner) and Y-score (partner→ZNF274) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.702	+3.321	<.001	.009	3	2
UCEC	TIGAR →	+0.188	+1.512	.002	.035	3	2
UCEC	eIF4E →	+0.225	+3.335	.007	.005	3	1
UCEC	ERK2 →	+0.267	+3.087	<.001	<.001	3	1
UCEC	GAPDH →	+0.496	+1.700	.021	.042	3	1
UCEC	ACC1 →	+0.377	+3.183	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

TFRC by ZNF274 expression — UCEC

Explore this box plot interactively →