ZNF274

Across TCGA cell cohorts, ZNF274 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,093 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ZNF274-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Negative regulation of myoblast fusion, and Heterochromatin organization. Each is linked with ZNF274 in more than 11 cancer types. Because this analysis shows association rather than direction, both ZNF274-to-partner and partner-to-ZNF274 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by ZNF274-low versus ZNF274-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF274→partner) and Y-score (partner→ZNF274) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of gene expression, epigenetic →	+0.046	+1.096	<.001	.002	3	12
BREAST	Negative regulation of myoblast fusion →	+0.092	+1.035	<.001	<.001	3	10
OESOPHAGUS	Heterochromatin organization →	+0.041	+1.042	<.001	.005	2	11
UPPER_AERODIGESTIVE_TRACT	Establishment of protein localization to organelle →	+0.042	+0.649	.005	.002	2	11
LUNG_SCLC	Protein localization to vacuole →	+0.060	+0.587	.004	.006	3	10
BREAST	Nucleic acid transport →	+0.105	+1.165	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,093 associations by consensus.

Negative regulation of gene expression, epigenetic by ZNF274 expression — LARGE_INTESTINE

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