ZNF274

Across TCGA cell cohorts, ZNF274 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF274-associated genes across cancer lineages are ANKRD30BL, OR11H12, and SLC7A10. Each is linked with ZNF274 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF274-to-partner and partner-to-ZNF274 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD30BL grouped by ZNF274-low versus ZNF274-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF274→partner) and Y-score (partner→ZNF274) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ANKRD30BL →	+0.656	+3.289	<.001	.009	3	2
LARGE_INTESTINE	OR11H12 →	+0.159	+3.345	<.001	.007	3	1
SKIN	SLC7A10 →	+0.390	+4.095	<.001	.009	3	1
SKIN	OR1L3 →	+0.022	+4.415	<.001	.007	3	1
SKIN	KCNK16 →	+0.049	+4.930	<.001	.001	3	1
BLOOD_Leukemia	CST4 →	+0.040	+3.450	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

ANKRD30BL by ZNF274 expression — BLOOD_Leukemia

Explore this box plot interactively →