Across TCGA patient cohorts, ZNF273 mutation is significantly associated with the RNA expression of many other genes, with 1,563 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF273-associated genes across cancer lineages are VPS18, MRPS11, and UBFD1P1. Each is linked with ZNF273 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF273-to-partner and partner-to-ZNF273 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF273→partner) and Y-score (partner→ZNF273) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VPS18 →	+0.406	+3.480	.005	.002	3	3
UCEC	MRPS11 →	+0.305	+2.627	.006	.005	3	3
SKCM	UBFD1P1 →	+0.019	+4.039	<.001	.009	3	2
SKCM	TUBB8P3 →	+0.028	+3.360	.001	.006	3	2
READ	RN7SL22P →	+0.238	+5.039	.005	.008	3	2
UCEC	MRPL49 →	+0.452	+2.103	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,563 associations by consensus.

Exploration

ZNF273 survival (RNA) · tumor vs normal (RNA) · all ZNF273 data types