ZNF273

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, ZNF273 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF273-associated genes across cancer lineages are FoxM1, PCNA, and Caspase-7-cleavedD198. Each is linked with ZNF273 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF273-to-partner and partner-to-ZNF273 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF273→partner) and Y-score (partner→ZNF273) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECFoxM1 →+0.230+2.087.020.00532
COADPCNA →+0.327+3.008.011.01932
UCECCaspase-7-cleavedD198 →+0.555+1.720.014.02532
UCECCaspase-8 →-0.232-2.584.016.00132
UCECCyclin-B1 →+0.651+2.584.002.01032
COADPKC-b-II_pS660 →-0.539-3.000.003.03532
Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration