Across TCGA cell cohorts, ZNF273 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF273-associated genes across cancer lineages are ASPN, DEFA4, and TBC1D21. Each is linked with ZNF273 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF273-to-partner and partner-to-ZNF273 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF273→partner) and Y-score (partner→ZNF273) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASPN →	+0.042	+3.426	.001	.007	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR6Q1 →	+0.012	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TEX101 →	+0.250	+3.708	<.001	.004	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

ZNF273 survival (RNA) · tumor vs normal (RNA) · all ZNF273 data types