ZNF268

Across TCGA patient cohorts, ZNF268 mutation is significantly associated with the RNA expression of many other genes, with 4,719 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF268-associated genes across cancer lineages are RNU6-1214P, RNU6-1327P, and CYCSP12. Each is linked with ZNF268 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF268-to-partner and partner-to-ZNF268 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1214P grouped by ZNF268-low versus ZNF268-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF268→partner) and Y-score (partner→ZNF268) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-1214P →	+0.530	+5.306	<.001	.006	3	2
SARC	RNU6-1327P →	+0.504	+5.111	<.001	.008	3	2
LUAD	CYCSP12 →	+0.189	+4.798	<.001	.006	3	2
UCEC	MIR1298 →	+0.027	+3.451	<.001	.008	3	2
UCEC	RNU6ATAC17P →	+0.136	+1.760	.002	.002	3	2
LUAD	RNU5E-9P →	+0.252	+6.333	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,719 associations by consensus.

RNU6-1214P by ZNF268 expression — CESC

Explore this box plot interactively →