ZNF268

Across TCGA patient cohorts, ZNF268 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF268-associated genes across cancer lineages are FoxM1, PCNA, and EGFR_pY1068. Each is linked with ZNF268 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF268-to-partner and partner-to-ZNF268 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by ZNF268-low versus ZNF268-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF268→partner) and Y-score (partner→ZNF268) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.189	+1.106	.009	.020	3	2
UCEC	PCNA →	+0.218	+1.830	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.181	-0.947	.010	.047	3	1
UCEC	eIF4E →	+0.163	+2.335	.006	.002	3	1
UCEC	ERK2 →	+0.124	+1.584	.022	.008	3	1
UCEC	Fibronectin →	-0.201	-1.191	.030	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

FoxM1 by ZNF268 expression — UCEC

Explore this box plot interactively →