ZNF266

Across TCGA pan-cancer cohorts, ZNF266 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ZNF266 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ZNF266 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF266 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

CESC, COAD, and READ are the cancer types where ZNF266 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.068	0.875	<.001	36	view →
COAD	OS	Median	All	0.132	0.674	.001	20	view →
READ	OS	Median	II,III,IV	0.527	0.933	<.001	9	view →
HNSC	OS	Median	All	0.438	0.770	.027	6	view →
SKCM	DFS	Median	All	0.905	0.612	.014	4	view →
SCLC	OS	Median	II,III,IV	0.152	0.777	.038	3	view →
LIHC	OS	Median	II,III,IV	0.239	0.715	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ZNF266–CESC (OS)

Open the CESC breakdown →