ZNF266

Across TCGA patient cohorts, ZNF266 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF266-associated genes across cancer lineages are MEK1, BRD4, and ERK2. Each is linked with ZNF266 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF266-to-partner and partner-to-ZNF266 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZNF266-low versus ZNF266-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF266→partner) and Y-score (partner→ZNF266) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.323	+1.847	.008	.007	3	2
COAD	BRD4 →	+0.464	+2.821	.009	.035	3	2
UCEC	ERK2 →	+0.187	+1.321	.003	.029	3	2
UCEC	PCNA →	+0.222	+1.874	.002	.002	3	2
UCEC	Annexin-1 →	+0.483	+1.827	.006	.015	3	2
UCEC	Bax →	+0.200	+1.321	.012	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

MEK1 by ZNF266 expression — UCEC

Explore this box plot interactively →