ZNF266

Across TCGA cell cohorts, ZNF266 mutation is significantly associated with the mutation status of many other genes, with 3,488 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF266-associated genes across cancer lineages are HGF, RRP12, and WDR62. Each is linked with ZNF266 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF266-to-partner and partner-to-ZNF266 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HGF grouped by ZNF266-low versus ZNF266-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF266→partner) and Y-score (partner→ZNF266) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HGF →	+3.222	+2.893	.003	.003	1	3
SKIN	RRP12 →	+3.210	+3.548	.001	.001	1	3
SKIN	WDR62 →	+3.532	+4.285	<.001	<.001	1	3
SKIN	ITGAE →	+4.117	+3.638	.002	.002	1	3
SKIN	GRAMD1A →	+3.532	+3.357	.005	.005	1	3
SKIN	KCNH4 →	+3.532	+3.357	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,488 associations by consensus.

HGF by ZNF266 expression — LARGE_INTESTINE

Explore this box plot interactively →