ZNF264

Across TCGA patient cohorts, ZNF264 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF264-associated genes across cancer lineages are Caspase-7-cleavedD198, GAPDH, and MEK1. Each is linked with ZNF264 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF264-to-partner and partner-to-ZNF264 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZNF264-low versus ZNF264-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF264→partner) and Y-score (partner→ZNF264) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.743	+3.267	<.001	<.001	3	3
UCEC	GAPDH →	+0.430	+1.999	.013	.008	3	2
UCEC	MEK1 →	+0.375	+2.000	.001	<.001	3	2
UCEC	P-Cadherin →	-0.101	-2.584	.030	.010	3	2
UCEC	PCNA →	+0.242	+2.321	<.001	<.001	3	2
UCEC	PDCD4 →	-0.602	-2.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by ZNF264 expression — UCEC

Explore this box plot interactively →