ZNF263

Across TCGA patient cohorts, ZNF263 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF263-associated genes across cancer lineages are p53, Src_pY527, and 14-3-3_beta. Each is linked with ZNF263 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF263-to-partner and partner-to-ZNF263 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p53 grouped by ZNF263-low versus ZNF263-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF263→partner) and Y-score (partner→ZNF263) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p53 →	-0.301	-2.321	.047	.034	3	2
UCEC	Src_pY527 →	-0.495	-3.449	.003	.005	3	2
UCEC	14-3-3_beta →	-0.101	-3.432	.010	.005	3	1
UCEC	EGFR_pY1068 →	-0.337	-3.459	<.001	.005	3	1
UCEC	eIF4E →	+0.179	+2.000	.031	.010	2	2
UCEC	Fibronectin →	-0.265	-2.449	.040	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

p53 by ZNF263 expression — UCEC

Explore this box plot interactively →