Across TCGA patient cohorts, ZNF257 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF257-associated genes across cancer lineages are eIF4G, S6_pS240_S244, and TIGAR. Each is linked with ZNF257 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF257-to-partner and partner-to-ZNF257 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF257→partner) and Y-score (partner→ZNF257) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.232	+1.807	.013	.024	3	3
BLCA	S6_pS240_S244 →	+0.529	+3.000	.005	.036	3	2
LUSC	TIGAR →	+0.196	+3.045	<.001	<.001	3	2
COAD	ASNS →	+0.566	+3.008	.005	.019	3	2
UCEC	p27 →	-0.164	-1.321	.012	.012	3	2
UCEC	p62 Lck ligand →	+0.300	+1.672	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Exploration

ZNF257 survival (RNA) · tumor vs normal (RNA) · all ZNF257 data types