Across TCGA patient cohorts, ZNF254 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF254-associated genes across cancer lineages are eIF4E, MEK1, and mTOR_pS2448. Each is linked with ZNF254 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF254-to-partner and partner-to-ZNF254 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF254→partner) and Y-score (partner→ZNF254) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.242	+3.000	<.001	<.001	3	2
UCEC	MEK1 →	+0.418	+2.169	<.001	.003	3	2
UCEC	mTOR_pS2448 →	-0.144	-2.986	.002	<.001	3	2
UCEC	p62 Lck ligand →	+0.449	+3.999	<.001	<.001	3	2
UCEC	P-Cadherin →	-0.095	-2.584	.042	.010	3	2
UCEC	PDCD4 →	-0.515	-1.716	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Exploration

ZNF254 survival (RNA) · tumor vs normal (RNA) · all ZNF254 data types