Across TCGA patient cohorts, ZNF251 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF251-associated genes across cancer lineages are FoxM1, S6_pS240_S244, and Caspase-7-cleavedD198. Each is linked with ZNF251 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF251-to-partner and partner-to-ZNF251 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF251→partner) and Y-score (partner→ZNF251) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.234	+1.925	.012	.005	3	3
UCEC	S6_pS240_S244 →	+0.405	+2.584	.005	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.589	+2.807	.005	.002	3	2
UCEC	4E-BP1_pT70 →	+0.114	+2.459	.005	.018	3	2
UCEC	Cyclin-B1 →	+0.838	+3.459	<.001	<.001	3	2
UCEC	EGFR →	-0.190	-1.700	<.001	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

ZNF251 survival (RNA) · tumor vs normal (RNA) · all ZNF251 data types