ZNF25

Across TCGA pan-cancer cohorts, ZNF25 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZNF25 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ZNF25 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF25 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where ZNF25 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	III,IV	0.738	0.970	.038	6	view →
CCRCC	DFS	Median	III,IV	0.701	0.422	.024	3	view →
LUAD	OS	Quartile	All	0.758	0.951	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZNF25–LSCC (OS)

Open the LSCC breakdown →