ZNF25

Across TCGA patient cohorts, ZNF25 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF25-associated genes across cancer lineages are JNK2, Shc_pY317, and EGFR_pY1068. Each is linked with ZNF25 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF25-to-partner and partner-to-ZNF25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by ZNF25-low versus ZNF25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF25→partner) and Y-score (partner→ZNF25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.267	+3.594	<.001	.001	3	2
UCEC	Shc_pY317 →	-0.183	-2.321	.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.270	-2.662	.004	<.001	3	1
UCEC	EGFR →	-0.196	-3.143	.001	.018	3	1
UCEC	A-Raf_pS299 →	-0.139	-1.700	.001	.042	3	1
UCEC	FOXO3a_pS318_S321 →	-0.094	-1.797	.045	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

JNK2 by ZNF25 expression — UCEC

Explore this box plot interactively →