Across TCGA patient cohorts, ZNF248 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF248-associated genes across cancer lineages are ERK2, p70-S6K_pT389, and PCNA. Each is linked with ZNF248 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF248-to-partner and partner-to-ZNF248 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF248→partner) and Y-score (partner→ZNF248) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.254	+2.999	<.001	<.001	3	2
UCEC	p70-S6K_pT389 →	-0.190	-2.700	.002	.005	3	2
UCEC	PCNA →	+0.258	+3.058	<.001	<.001	3	2
UCEC	PDCD4 →	-0.572	-1.584	<.001	.009	3	2
UCEC	S6_pS240_S244 →	+0.366	+3.700	.007	.001	3	2
UCEC	TFRC →	+0.584	+3.700	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Exploration

ZNF248 survival (RNA) · tumor vs normal (RNA) · all ZNF248 data types