Across TCGA cell cohorts, ZNF248 mutation is significantly associated with the drug of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF248-associated genes across cancer lineages are Leflunomide, 50869, and KIN001-042. Each is linked with ZNF248 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF248-to-partner and partner-to-ZNF248 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF248→partner) and Y-score (partner→ZNF248) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Leflunomide →	+0.303	+2.678	.017	.037	3	1
LARGE_INTESTINE	50869 →	+0.546	+2.678	.008	.037	3	1
LARGE_INTESTINE	KIN001-042 →	+0.298	+2.652	.010	.045	3	1
LARGE_INTESTINE	FTY-720 →	+0.231	+2.722	.024	.040	3	1
LARGE_INTESTINE	SGC-CBP30 →	+0.310	+2.649	.028	.046	2	1
LARGE_INTESTINE	TL-2-105 →	+0.455	+2.652	.020	.045	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

ZNF248 survival (RNA) · tumor vs normal (RNA) · all ZNF248 data types