ZNF236

Across TCGA patient cohorts, ZNF236 mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF236-associated genes across cancer lineages are Cyclin-B1, 4E-BP1, and eIF4E. Each is linked with ZNF236 in more than 5 cancer types. Because this analysis shows association rather than direction, both ZNF236-to-partner and partner-to-ZNF236 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ZNF236-low versus ZNF236-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF236→partner) and Y-score (partner→ZNF236) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.542	+3.247	<.001	<.001	3	6
STAD	4E-BP1 →	+0.397	+3.321	.004	.010	3	4
UCEC	eIF4E →	+0.219	+2.440	<.001	<.001	3	3
COAD	mTOR_pS2448 →	-0.219	-2.982	.002	.034	3	3
COAD	Rad50 →	-0.348	-1.991	<.001	.031	3	3
COAD	ATM →	-0.591	-3.000	<.001	.034	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

Cyclin-B1 by ZNF236 expression — UCEC

Explore this box plot interactively →