ZNF233

Across TCGA patient cohorts, ZNF233 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF233-associated genes across cancer lineages are MEK1, MSH2, and p62 Lck ligand. Each is linked with ZNF233 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF233-to-partner and partner-to-ZNF233 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZNF233-low versus ZNF233-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF233→partner) and Y-score (partner→ZNF233) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.342	+3.000	.009	<.001	3	2
UCEC	MSH2 →	-0.217	-2.089	.009	.016	3	1
UCEC	p62 Lck ligand →	+0.309	+3.817	.008	<.001	3	1
UCEC	p90 RSK →	+0.165	+2.125	.016	.010	3	1
UCEC	PDK1_pS241 →	+0.131	+2.700	.033	.006	3	1
UCEC	PDK1 →	+0.080	+3.183	.038	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MEK1 by ZNF233 expression — UCEC

Explore this box plot interactively →