ZNF230

Across TCGA patient cohorts, ZNF230 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF230-associated genes across cancer lineages are PCNA, ACC1, and eIF4E. Each is linked with ZNF230 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF230-to-partner and partner-to-ZNF230 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ZNF230-low versus ZNF230-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF230→partner) and Y-score (partner→ZNF230) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PCNA →	+0.220	+3.009	.047	.019	3	2
SKCM	ACC1 →	+0.278	+2.000	.045	.031	3	2
UCEC	eIF4E →	+0.204	+2.807	.007	<.001	3	2
UCEC	INPP4B →	-0.367	-2.906	.001	.001	3	2
SKCM	Src →	-0.254	-2.000	.013	.031	3	1
UCEC	14-3-3_beta →	-0.100	-2.088	.005	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

PCNA by ZNF230 expression — LUSC

Explore this box plot interactively →