ZNF23

Across TCGA patient cohorts, ZNF23 mutation is significantly associated with the RNA expression of many other genes, with 4,134 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF23-associated genes across cancer lineages are MIR875, RNA5SP48, and SNORA108. Each is linked with ZNF23 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF23-to-partner and partner-to-ZNF23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR875 grouped by ZNF23-low versus ZNF23-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF23→partner) and Y-score (partner→ZNF23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR875 →	+0.272	+4.526	<.001	.007	3	2
LUSC	RNA5SP48 →	+0.327	+4.262	<.001	<.001	3	2
LUSC	SNORA108 →	+0.189	+5.008	<.001	.002	3	2
LUSC	RNU6-579P →	+0.237	+3.356	.001	.007	3	2
UCEC	GZMB →	+1.358	+2.273	<.001	<.001	3	2
UCEC	CDKN3 →	+0.885	+2.595	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,134 associations by consensus.

MIR875 by ZNF23 expression — HNSC

Explore this box plot interactively →