ZNF23

Across TCGA patient cohorts, ZNF23 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF23-associated genes across cancer lineages are Notch1, Caspase-7-cleavedD198, and eEF2. Each is linked with ZNF23 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF23-to-partner and partner-to-ZNF23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ZNF23-low versus ZNF23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF23→partner) and Y-score (partner→ZNF23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.151	+1.584	.001	.009	3	3
UCEC	Caspase-7-cleavedD198 →	+0.546	+1.926	.006	.008	3	3
UCEC	eEF2 →	+0.237	+2.321	.048	.033	3	2
UCEC	A-Raf_pS299 →	-0.113	-2.502	.004	.001	3	2
UCEC	mTOR_pS2448 →	-0.102	-2.102	.041	.016	3	2
UCEC	PCNA →	+0.240	+3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Notch1 by ZNF23 expression — UCEC

Explore this box plot interactively →