ZNF227

Across TCGA pan-cancer cohorts, ZNF227 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZNF227 data layer compared with 21 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher ZNF227 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF227 expression acts as an unfavorable survival marker.

SKCM, COAD, and LIHC are the cancer types where ZNF227 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.102	0.765	<.001	21	view →
COAD	OS	Median	IV	0.045	0.659	<.001	12	view →
LIHC	OS	Median	All	0.268	0.710	.012	9	view →
LUSC	DFS	Median	II,III,IV	0.168	0.612	.008	6	view →
BLCA	OS	Median	IV	0.133	0.589	.006	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZNF227–SKCM (DFS)

Open the SKCM breakdown →