ZNF227

Across TCGA patient cohorts, ZNF227 protein abundance is significantly associated with the RNA expression of many other genes, with 210 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ZNF227-associated genes across cancer lineages are SPEF1, WFS1, and SLC38A1. Each is linked with ZNF227 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF227-to-partner and partner-to-ZNF227 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZNF227 versus SPEF1 in LSCC, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF227→partner) and Y-score (partner→ZNF227) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPEF1 →	+0.640	+0.591	.001	<.001	3	1
LSCC	WFS1 →	+0.631	+0.487	.005	.009	3	1
LSCC	SLC38A1 →	+0.968	+0.660	.006	.006	3	1
LSCC	SLC19A2 →	+0.995	+0.638	.001	.006	3	1
LSCC	DYDC2 →	+0.641	+0.576	.001	.001	3	1
LSCC	PRKG2 →	+0.885	+0.501	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 210 associations by consensus.

ZNF227 vs SPEF1 — LSCC

Explore this scatter interactively →