ZNF227

Across TCGA cell cohorts, ZNF227 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,230 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF227-associated GO terms across cancer lineages are Heterochromatin formation, Negative regulation of gene expression, epigenetic, and Epigenetic regulation of gene expression. Each is linked with ZNF227 in more than 14 cancer types. Because this analysis shows association rather than direction, both ZNF227-to-partner and partner-to-ZNF227 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin formation grouped by ZNF227-low versus ZNF227-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF227→partner) and Y-score (partner→ZNF227) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Heterochromatin formation →	+0.091	+0.993	.001	<.001	3	15
STOMACH	Negative regulation of gene expression, epigenetic →	+0.090	+0.856	.001	.001	3	15
STOMACH	Epigenetic regulation of gene expression →	+0.084	+1.027	<.001	<.001	3	14
STOMACH	Heterochromatin organization →	+0.087	+0.948	.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Nucleocytoplasmic transport →	+0.061	+0.590	.002	<.001	3	13
LUNG_SCLC	Regulation of centrosome cycle →	+0.094	+0.539	.003	.009	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,230 associations by consensus.

Heterochromatin formation by ZNF227 expression — STOMACH

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