ZNF225

Across TCGA patient cohorts, ZNF225 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF225-associated genes across cancer lineages are Notch1, ER-alpha_pS118, and mTOR_pS2448. Each is linked with ZNF225 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF225-to-partner and partner-to-ZNF225 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ZNF225-low versus ZNF225-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF225→partner) and Y-score (partner→ZNF225) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.183	+1.807	.001	.027	3	2
UCEC	ER-alpha_pS118 →	-0.308	-2.321	.038	.006	3	1
UCEC	mTOR_pS2448 →	-0.165	-3.308	.007	.009	3	1
UCEC	p62 Lck ligand →	+0.383	+3.594	.004	.001	3	1
UCEC	PDCD4 →	-0.622	-3.321	.001	.009	3	1
UCEC	PDK1_pS241 →	+0.184	+2.584	.009	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Notch1 by ZNF225 expression — UCEC

Explore this box plot interactively →