ZNF223

Across TCGA patient cohorts, ZNF223 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF223-associated genes across cancer lineages are JNK_pT183_Y185, Rab25, and Cyclin-E2. Each is linked with ZNF223 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF223-to-partner and partner-to-ZNF223 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by ZNF223-low versus ZNF223-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF223→partner) and Y-score (partner→ZNF223) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.175	-2.321	.014	.034	3	2
UCEC	Rab25 →	-0.508	-2.222	<.001	.011	3	2
UCEC	Cyclin-E2 →	+0.162	+2.179	.023	.034	3	2
UCEC	EGFR_pY1068 →	-0.336	-4.000	.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.118	-2.321	.020	.034	3	1
UCEC	FASN →	+0.521	+2.321	.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

JNK_pT183_Y185 by ZNF223 expression — UCEC

Explore this box plot interactively →