ZNF222

Across TCGA patient cohorts, ZNF222 mutation is significantly associated with the RNA expression of many other genes, with 2,100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF222-associated genes across cancer lineages are BRD9P1, IGF2, and REXO1L8P. Each is linked with ZNF222 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF222-to-partner and partner-to-ZNF222 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRD9P1 grouped by ZNF222-low versus ZNF222-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF222→partner) and Y-score (partner→ZNF222) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BRD9P1 →	+0.142	+6.315	<.001	.001	3	2
UCEC	IGF2 →	-1.808	-2.398	.001	.003	3	2
BLCA	REXO1L8P →	+0.033	+4.497	.004	.009	3	2
UCEC	C2CD4B →	-1.231	-2.807	<.001	.003	3	2
UCEC	TRAJ43 →	+0.555	+1.889	<.001	.002	3	2
LUSC	RNU6ATAC33P →	+0.253	+4.993	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,100 associations by consensus.

BRD9P1 by ZNF222 expression — LUAD

Explore this box plot interactively →