ZNF222

Across TCGA patient cohorts, ZNF222 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF222-associated genes across cancer lineages are VHL, FoxM1, and Ku80. Each is linked with ZNF222 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF222-to-partner and partner-to-ZNF222 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by ZNF222-low versus ZNF222-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF222→partner) and Y-score (partner→ZNF222) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.926	-3.169	<.001	<.001	3	2
UCEC	FoxM1 →	+0.208	+2.000	.041	.010	3	1
UCEC	Ku80 →	+0.220	+1.598	.017	.022	3	1
UCEC	MEK1 →	+0.313	+1.584	.029	.036	3	1
UCEC	p62 Lck ligand →	+0.307	+2.459	.016	.018	3	1
UCEC	S6_pS240_S244 →	+0.392	+2.321	.014	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

VHL by ZNF222 expression — UCEC

Explore this box plot interactively →