ZNF222

Across TCGA cell cohorts, ZNF222 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ZNF222-associated genes across cancer lineages are OR10A3, TAAR6, and CHRNB3. Each is linked with ZNF222 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF222-to-partner and partner-to-ZNF222 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A3 grouped by ZNF222-low versus ZNF222-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF222→partner) and Y-score (partner→ZNF222) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10A3 →	+0.045	+5.539	<.001	.003	3	1
SKIN	TAAR6 →	+0.072	+4.467	<.001	.004	3	1
SKIN	CHRNB3 →	+0.011	+4.467	<.001	.004	3	1
SKIN	HSFY1 →	+0.010	+5.022	<.001	.002	3	1
SKIN	CASP12 →	+0.053	+4.095	<.001	.009	3	1
SKIN	MDFIC2 →	+0.126	+5.562	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR10A3 by ZNF222 expression — BLOOD_Leukemia

Explore this box plot interactively →