ZNF221

Across TCGA patient cohorts, ZNF221 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,970 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ZNF221-associated proteins across cancer lineages are TRIM28, HNRNPLL, and ALG1. Each is linked with ZNF221 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZNF221-to-partner and partner-to-ZNF221 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZNF221 versus TRIM28 in GBM, with a Pearson correlation of 0.59.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF221→partner) and Y-score (partner→ZNF221) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRIM28 →	+0.436	+0.569	<.001	<.001	3	5
GBM	HNRNPLL →	+0.226	+0.447	<.001	<.001	3	5
HNSC	ALG1 →	-0.279	-0.817	.001	<.001	3	5
GBM	PPP4R3A →	+0.362	+0.588	<.001	<.001	3	4
PDAC	PARP12 →	-0.344	-0.383	<.001	<.001	3	4
PDAC	ZNF428 →	+0.444	+0.366	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,970 associations by consensus.

ZNF221 vs TRIM28 — GBM

Explore this scatter interactively →