ZNF221

Across TCGA patient cohorts, ZNF221 mutation is significantly associated with the RNA expression of many other genes, with 2,335 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF221-associated genes across cancer lineages are SNRNP25, SEC13, and DEDD2. Each is linked with ZNF221 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF221-to-partner and partner-to-ZNF221 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRNP25 grouped by ZNF221-low versus ZNF221-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF221→partner) and Y-score (partner→ZNF221) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRNP25 →	+0.353	+1.791	.003	.002	3	3
UCEC	SEC13 →	+0.379	+2.321	<.001	<.001	3	2
UCEC	DEDD2 →	+0.318	+1.737	.002	.002	3	2
UCEC	PRSS12 →	-1.201	-2.321	<.001	<.001	3	2
UCEC	POLR2G →	+0.301	+1.769	.008	.002	3	2
UCEC	IFFO2 →	-0.533	-2.311	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,335 associations by consensus.

SNRNP25 by ZNF221 expression — UCEC

Explore this box plot interactively →