ZNF221

Across TCGA patient cohorts, ZNF221 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF221-associated genes across cancer lineages are C-Raf, MEK1, and PDCD4. Each is linked with ZNF221 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF221-to-partner and partner-to-ZNF221 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by ZNF221-low versus ZNF221-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF221→partner) and Y-score (partner→ZNF221) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.169	+1.906	<.001	.015	3	3
UCEC	MEK1 →	+0.548	+2.874	<.001	<.001	3	2
UCEC	PDCD4 →	-0.517	-2.115	.001	.016	3	2
UCEC	Shc_pY317 →	-0.196	-1.662	<.001	.011	3	2
UCEC	ASNS →	+0.320	+1.362	.012	.037	3	2
UCEC	ATM →	-0.657	-4.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

C-Raf by ZNF221 expression — UCEC

Explore this box plot interactively →