ZNF221

Across TCGA cell cohorts, ZNF221 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,043 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ZNF221-associated GO terms across cancer lineages are RNA localization, DNA biosynthetic process, and Heterochromatin formation. Each is linked with ZNF221 in more than 12 cancer types. Because this analysis shows association rather than direction, both ZNF221-to-partner and partner-to-ZNF221 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA localization grouped by ZNF221-low versus ZNF221-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF221→partner) and Y-score (partner→ZNF221) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RNA localization →	+0.094	+0.712	<.001	<.001	3	13
SOFT_TISSUE	DNA biosynthetic process →	+0.076	+0.944	<.001	<.001	3	13
STOMACH	Heterochromatin formation →	+0.082	+0.765	.001	.008	2	13
SOFT_TISSUE	Protein localization to nucleus →	+0.054	+0.894	.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of gene expression, epigenetic →	+0.062	+0.503	<.001	.001	3	12
SOFT_TISSUE	Nuclear export →	+0.091	+0.875	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,043 associations by consensus.

RNA localization by ZNF221 expression — BREAST

Explore this box plot interactively →