ZNF221

Across TCGA cell cohorts, ZNF221 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZNF221-associated genes across cancer lineages are OR10A4, OR6B3, and KRTAP10-10. Each is linked with ZNF221 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF221-to-partner and partner-to-ZNF221 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A4 grouped by ZNF221-low versus ZNF221-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF221→partner) and Y-score (partner→ZNF221) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10A4 →	+0.056	+3.938	.001	.002	3	1
BLOOD_Lymphoma	OR6B3 →	+0.038	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	KRTAP10-10 →	+0.014	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	OR4A47 →	+0.016	+4.643	<.001	.005	3	1
LUNG_SCLC	OR8B8 →	+0.062	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR10A4 by ZNF221 expression — LARGE_INTESTINE

Explore this box plot interactively →