ZNF22

Across TCGA patient cohorts, ZNF22 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF22-associated genes across cancer lineages are Caspase-7-cleavedD198, HER3_pY1289, and ACVRL1. Each is linked with ZNF22 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF22-to-partner and partner-to-ZNF22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZNF22-low versus ZNF22-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF22→partner) and Y-score (partner→ZNF22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.543	+3.008	<.001	.019	3	2
UCEC	HER3_pY1289 →	+0.076	+2.189	.024	.034	3	2
UCEC	ACVRL1 →	-0.141	-1.861	.008	.049	3	2
UCEC	STAT3_pY705 →	-0.489	-2.222	<.001	.009	3	2
UCEC	EGFR_pY1068 →	-0.219	-1.584	.026	.036	3	1
UCEC	INPP4B →	-0.256	-1.874	.044	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Caspase-7-cleavedD198 by ZNF22 expression — COAD

Explore this box plot interactively →