ZNF219

Across TCGA patient cohorts, ZNF219 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF219-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and JNK2. Each is linked with ZNF219 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF219-to-partner and partner-to-ZNF219 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZNF219-low versus ZNF219-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF219→partner) and Y-score (partner→ZNF219) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.271	-3.459	.031	.005	3	1
UCEC	eIF4E →	+0.240	+3.459	.023	.005	3	1
UCEC	JNK2 →	+0.270	+2.321	.006	.035	3	1
UCEC	p62 Lck ligand →	+0.519	+3.179	.001	.010	3	1
UCEC	PDK1_pS241 →	+0.241	+2.833	.004	.034	3	1
UCEC	SF2 →	-0.144	-2.311	.008	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR_pY1068 by ZNF219 expression — UCEC

Explore this box plot interactively →