ZNF219

Across TCGA cell cohorts, ZNF219 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,130 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF219-associated GO terms across cancer lineages are Negative regulation of DNA-templated transcription, elongation, Energy coupled proton transmembrane transport, against electrochemical gradient, and Electron transport coupled proton transport. Each is linked with ZNF219 in more than 14 cancer types. Because this analysis shows association rather than direction, both ZNF219-to-partner and partner-to-ZNF219 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of DNA-templated transcription, elongation grouped by ZNF219-low versus ZNF219-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF219→partner) and Y-score (partner→ZNF219) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of DNA-templated transcription, elongation →	+0.139	+2.162	.001	.003	3	15
OESOPHAGUS	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.133	+2.636	<.001	<.001	3	12
OESOPHAGUS	Electron transport coupled proton transport →	+0.133	+2.636	<.001	<.001	3	12
BONE	Negative regulation of RNA splicing →	+0.120	+1.698	<.001	<.001	3	12
BONE	Negative regulation of mRNA splicing, via spliceosome →	+0.126	+1.715	<.001	<.001	3	12
BONE	Negative regulation of mRNA processing →	+0.122	+1.715	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,130 associations by consensus.

Negative regulation of DNA-templated transcription, elongation by ZNF219 expression — OESOPHAGUS

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