ZNF219

Across TCGA cell cohorts, ZNF219 mutation is significantly associated with the RNA expression of many other genes, with 438 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF219-associated genes across cancer lineages are TBPL2, PTH2, and TAAR8. Each is linked with ZNF219 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF219-to-partner and partner-to-ZNF219 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBPL2 grouped by ZNF219-low versus ZNF219-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF219→partner) and Y-score (partner→ZNF219) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TBPL2 →	+0.105	+4.366	<.001	<.001	3	2
LUNG_NSCLC_LUAD	PTH2 →	+0.141	+4.481	<.001	.001	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OCSTAMP →	+0.011	+4.343	<.001	.002	3	1
LUNG_NSCLC_LUAD	UBQLN3 →	+0.009	+3.734	<.001	.006	3	1
LUNG_NSCLC_LUAD	BEND2 →	+0.010	+3.544	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 438 associations by consensus.

TBPL2 by ZNF219 expression — BLOOD_Leukemia

Explore this box plot interactively →